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The researchers evaluated both patients with CDAD requiring ICU placement and ICU patients whose CDAD was severe enough by itself to require critical care. The primary indications for surgery were perforation, shock resistant to pressor therapy, toxic megacolon, and failure to respond to medical therapy.

It is clear that some patients fare better with early intervention prior to the onset of severe multi-organ failure and concomitant severe lactic acidosis. Ultimately, surgery may confer the greatest benefit upon patients over 65 years of age, as well as patients whose lactate levels or white blood cell counts are continuing to rise despite therapy.

Other Antibiotics Several other antibiotics are being studied in the treatment of CDAD.